Surgery for Obesity and Related Diseases
Volume 4, Issue 2 , Pages 186-193 , March 2008

Contribution of obesity to pancreatic carcinogenesis

  • Andrew A. Gumbs, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Andrew A. Gumbs, M.D., Department of Surgery, Division of Upper Gastrointestinal and Endocrine Surgery, Columbia University College of Physicians and Surgeons, New York-Presbyterian Hospital, Herbert Irving Pavilion, 161 Fort Washington Ave, 8th Floor, New York, NY 10032.
  • ,
  • Marc Bessler, M.D.
  • ,
  • Luca Milone, M.D.
  • ,
  • Beth Schrope, M.D., Ph.D.
  • ,
  • John Chabot, M.D.

Received 23 July 2007 ,Revised 18 October 2007 ,Accepted 20 November 2007.

References 

  1. Fraumeni JF. Cancers of the pancreas and biliary tract: epidemiological considerations. Cancer Res. 1975;35:3437–3446
  2. Gumbs AA, Moore PS, Falconi M, et al. Review of the clinical, histological, and molecular aspects of pancreatic endocrine neoplasms. J Surg Oncol. 2002;81:45–54
  3. Freelove R, Walling AD. Pancreatic cancer: diagnosis and management. Am Fam Physician. 2006;73:485–492
  4. Michaud DS. Epidemiology of pancreatic cancer. Minerva Chir. 2004;59:99–111
  5. Weiderpass E, Partanen T, Kaaks R, et al. Occurrence, trends and environment etiology of pancreatic cancer. Scand J Work Environ Health. 1998;24:165–174
  6. Gumbs AA, Modlin IM, Ballantyne GH. Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes Surg. 2005;15:462–473
  7. Ballantyne GH, Gumbs A, Modlin IM. Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. Obes Surg. 2005;15:692–699
  8. Lynch HT, Brand RE, Lynch JF, et al. Hereditary factors in pancreatic cancer. J Hepatobiliary Pancreat Surg. 2002;9:12–31
  9. Schutte M, Hruban RH, Geradts J, et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997;57:3126–3130
  10. Goggins M, Schutte M, Lu J, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res. 1996;56:5360–5364
  11. Su GH, Hruban RH, Bansal RK, et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol. 1999;154:1835–1840
  12. Ozcelik H, Schmocker B, Di Nicola N, et al. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet. 1997;16:17–18
  13. Huang L, Lang D, Geradts J, et al. Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. Mol Carcinog. 1996;15:85–95
  14. Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350–353
  15. Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549–554
  16. Rozenblum E, Schutte M, Goggins M, et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 1997;57:1731–1734
  17. Wallrapp C, Muller-Pillasch F, Solinas-Toldo S, et al. Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene. Cancer Res. 1997;57:3135–3139
  18. Larsson SC, Permert J, Hakansson N, et al. Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. Br J Cancer. 2005;93:1310–1315
  19. Qiu D, Kurosawa M, Lin Y, et al. Overview of the epidemiology of pancreatic cancer focusing on the JACC Study. J Epidemiol. 2005;15(Suppl 2):S157–S167
  20. Lowenfels AB, Sullivan T, Fiorianti J, et al. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep. 2005;7:90–95
  21. Lowenfels AB, Maisonneuve P. Epidemiologic and etiologic factors of pancreatic cancer. Hematol Oncol Clin North Am. 2002;16:1–16
  22. Ji J, Hemminki K. Socioeconomic and occupational risk factors for pancreatic cancer: a cohort study in Sweden. J Occup Environ Med. 2006;48:283–288
  23. Ji BT, Hatch MC, Chow WH, et al. Anthropometric and reproductive factors and the risk of pancreatic cancer: a case-control study in Shanghai, China. Int J Cancer. 1996;66:432–437
  24. Guthrie N, Carroll KK. Specific versus non-specific effects of dietary fat on carcinogenesis. Prog Lipid Res. 1999;38:261–271
  25. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem. 2006;387:349–360
  26. Schernhammer ES, Hu FB, Giovannucci E, et al. Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts. Cancer Epidemiol Biomarkers Prev. 2005;14:2098–2105
  27. Silverman DT, Swanson CA, Gridley G, et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst. 1998;90:1710–1719
  28. Oh SW, Yoon YS, Shin SA. Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol. 2005;23:4742–4754
  29. Rapp K, Schroeder J, Klenk J, et al. Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer. 2005;93:1062–1067
  30. Pezzilli R, Morselli-Labate AM, Migliori M, et al. Obesity and the risk of pancreatic cancer: an Italian multicenter study. Pancreas. 2005;31:221–224
  31. Mori M, Saitoh S, Takagi S, et al. A review of cohort studies on the association between history of diabetes mellitus and occurrence of cancer. Asian Pacific J Cancer Prev. 2000;1:269–276
  32. Eberle CA, Bracci PM, Holly EA. Anthropometric factors and pancreatic cancer in a population-based case-control study in the San Francisco Bay area. Cancer Causes Control. 2005;16:1235–1244
  33. Fryzek JP, Schenk M, Kinnard M, et al. The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996–1999. Am J Epidemiol. 2005;162:222–228
  34. Wideroff L, Gridley G, Mellemkjaer L, et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst. 1997;89:1360–1365
  35. Schapira DV. Diet, obesity, fat distribution and cancer in women. J Am Med Womens Assoc. 1991;46:126–130
  36. Schapira DV. Nutrition and cancer prevention. Prim Care. 1992;19:481–491
  37. Patel AV, Rodriguez C, Bernstein L, et al. Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. cohort. Cancer Epidemiol Biomarkers Prev. 2005;14:459–466
  38. Michaud DS, Giovannucci E, Willett WC, et al. Physical activity, obesity, height, and the risk of pancreatic cancer. JAMA. 2001;286:921–929
  39. Sinner PJ, Schmitz KH, Anderson KE, et al. Lack of association of physical activity and obesity with incident pancreatic cancer in elderly women. Cancer Epidemiol Biomarkers Prev. 2005;14:1571–1573
  40. Berrington de Gonzalez A, Sweetland S, Spencer E. A meta-analysis of obesity and the risk of pancreatic cancer. Br J Cancer. 2003;89:519–523
  41. Silha JV, Krsek M, Sucharda P, et al. Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond). 2005;29:1308–1314
  42. Horiguchi N, Takayama H, Toyoda M, et al. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Oncogene. 2002;21:1791–1799
  43. Samanic C, Chow WH, Gridley G, et al. Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control. 2006;17:901–909
  44. Carroll KK. Obesity as a risk factor for certain types of cancer. Lipids. 1998;33:1055–1059
  45. Welsch T, Kleeff J, Seitz HK, et al. Update on pancreatic cancer and alcohol-associated risk. J Gastroenterol Hepatol. 2006;21(Suppl 3):S69–S75
  46. de la Torre A, Debiton E, Durand D, et al. Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Anticancer Res. 2005;25:3943–3949
  47. Valk EE, Hornstra G. Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review. Int J Vitam Nutr Res. 2000;70:31–42
  48. Furstenberger G, Krieg P, Muller-Decker K, et al. What are cyclooxygenases and lipoxygenases doing in the driver’s seat of carcinogenesis?. Int J Cancer. 2006;119:2247–2254
  49. Michaud DS, Skinner HG, Wu K, et al. Dietary patterns and pancreatic cancer risk in men and women. J Natl Cancer Inst. 2005;97:518–524
  50. Skinner HG, Michaud DS, Giovannucci E, et al. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev. 2006;15:1688–1695
  51. Skinner HG, Michaud DS, Giovannucci EL, et al. A prospective study of folate intake and the risk of pancreatic cancer in men and women. Am J Epidemiol. 2004;160:248–258
  52. Skinner HG, Michaud DS, Colditz GA, et al. Parity, reproductive factors, and the risk of pancreatic cancer in women. Cancer Epidemiol Biomarkers Prev. 2003;12:433–438
  53. Bugianesi E. Review article: steatosis, the metabolic syndrome and cancer. Aliment Pharmacol Ther. 2005;22(Suppl 2):40–43
  54. Friedman GD, van den Eeden SK. Risk factors for pancreatic cancer: an exploratory study. Int J Epidemiol. 1993;22:30–37
  55. Noy A, Bilezikian JP. Clinical review 63: Diabetes and pancreatic cancer: clues to the early diagnosis of pancreatic malignancy. J Clin Endocrinol Metab. 1994;79:1223–1231
  56. Jee SH, Ohrr H, Sull JW, et al. Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 2005;293:194–202
  57. Stolzenberg-Solomon RZ, Graubard BI, Chari S, et al. Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA. 2005;294:2872–2878
  58. Hanley AJ, Johnson KC, Villeneuve PJ, et al. Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system. Int J Cancer. 2001;94:140–147
  59. Boyd DB. Insulin and cancer. Integr Cancer Ther. 2003;2:315–329
  60. Spector SA, Olson ET, Gumbs AA, et al. Human insulin receptor and insulin signaling proteins in hepatic disease. J Surg Res. 1999;83:32–35
  61. Schneider MB, Matsuzaki H, Haorah J, et al. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology. 2001;120:1263–1270
  62. Stattin P, Lukanova A, Biessy C, et al. Obesity and colon cancer: does leptin provide a link?. Int J Cancer. 2004;109:149–152
  63. Somasundar P, Yu AK, Vona-Davis L, et al. Differential effects of leptin on cancer in vitro. J Surg Res. 2003;113:50–55
  64. Iwakura H, Hosoda K, Doi R, et al. Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I. J Clin Endocrinol Metab. 2002;87:4885–4888
  65. Duxbury MS, Waseem T, Ito H, et al. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun. 2003;309:464–468
  66. Bassi C, Salvia R, Gumbs AA, et al. The value of standard serum tumor markers in differentiating mucinous from serous cystic tumors of the pancreas: CEA, CA19-9, CA125, CA15-3. Langenbecks Arch Surg. 2002;387:281–285
  67. Hiyama E, Kodama T, Shinbara K, et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors. Cancer Res. 1997;57:326–331
  68. Lilley M, Gilchrist D. The hereditary spectrum of pancreatic cancer: the Edmonton experience. Can J Gastroenterol. 2004;18:17–21
  69. Bueno de Mesquita HB, Moerman CJ, Runia S, et al. Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas?. Int J Cancer. 1990;46:435–444
  70. Howe GR, Jain M, Miller AB. Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study. Int J Cancer. 1990;45:604–608
  71. Ghadirian P, Simard A, Baillargeon J, et al. Nutritional factors and pancreatic cancer in the francophone community in Montreal, Canada. Int J Cancer. 1991;47:1–6
  72. Zatonski W, Przewozniak K, Howe GR, et al. Nutritional factors and pancreatic cancer: a case-control study from southwest Poland. Int J Cancer. 1991;48:390–394
  73. Friedman GD, van den Eeden SK. Risk factors for pancreatic cancer: an exploratory study. Int J Epidemiol. 1993;22:30–37
  74. Shibata A, Mack TM, Paganini-Hill A, et al. A prospective study of pancreatic cancer in the elderly. Int J Cancer. 1994;58:46–49
  75. Silverman DT, Swanson CA, Gridley G, et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst. 1998;90:1710–1719
  76. Gapstur SM, Gann PH, Lowe W, et al. Abnormal glucose metabolism and pancreatic cancer mortality. JAMA. 2000;283:2552–2558
  77. Hanley AJ, Johnson KC, Villeneuve PJ, et al. Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system. Int J Cancer. 2001;94:140–147
  78. Lee IM, Sesso HD, Oguma Y, et al. Physical activity, body weight, and pancreatic cancer mortality. Br J Cancer. 2003;88:679–683
  79. Calle ER, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med. 2003;348:1625–1638
  80. Duell EJ, Casella DP, Burk RD, et al. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:726–731
  81. Service GJ, Thompson GB, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med. 2005;353:249–254

PII: S1550-7289(07)00781-2

doi: 10.1016/j.soard.2007.11.009

Surgery for Obesity and Related Diseases
Volume 4, Issue 2 , Pages 186-193 , March 2008