Surgery for Obesity and Related Diseases
Volume 1, Issue 1 , Pages 25-34 , January 2005

The pathogenesis of obesity: Stress and the brain-gut axis

  • John G. Kral, M.D., Ph.D.

      Affiliations

    • Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York
    • Corresponding Author InformationReprint requests: John G. Kral, M.D., Ph.D., Department of Surgery, Box 40, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203.

References 

  1. Kennedy GC . The role of depot fat in the hypothalamic control of food intake in the rat . Proc Royal Soc . 1953;140:578–592
  2. Mayer J . Regulation of energy intake and the body weight (the glucostatic theory and the lipostatic hypothesis) . Ann NY Acad Sci . 1955;63:15–43
  3. Cohn C , Joseph D . Influence of body weight and body fat on appetite of “normal” lean and obese rats . Yale J Biol Med . 1962;34:598–607
  4. da Silva XG , Leclerc I , Salt IP , et al.   Role of AMP-activated protein kinase in the regulation by glucoses of islet beta cell gene expression . Proc Natl Acad Sci USA . 2000;97:4023–4028
  5. Andersson U , Filipsson K , Abbott CR , et al.   AMP-activated protein kinase plays a role in the control of food intake . J Biol Chem . 2004;279:12005–12008
  6. Neel J . Diabetes mellitus (a “thrifty” genotype rendered by “progress”?) . Am J Hum Genet . 1962;14:353–362
  7. Björntorp P . Thrifty genes and human obesity (are we chasing ghosts?) . Lancet . 2001;358:1006–1008
  8. Diamond J . The double puzzle of diabetes . Nature . 2003;423:599–602
  9. Holland ND . Early central nervous system evolution (an era of skin brains?) . Nat Rev Neurosci . 2003;4:617–627
  10. Hetherington AM , Woodward FI . The role of stomata in sensing and driving environmental change . Nature . 2003;424:901–908
  11. Gstaiger M , Luke B , Hess D , et al.   Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI . Science . 2003;302:1208–1212
  12. Hay N , Sonenberg N . Upstream and downstream of mTOR . Genes Dev . 2004;18:1926–1945
  13. Klingenberg M , Echtay KS . Uncoupling proteins (the issues from a biochemist point of view) . Biochim Biophys Acta . 2001;504:128–143
  14. Echtay KS , Roussel D , St Pierre J , et al.   Superoxide activates mitochondrial uncoupling proteins . Nature . 2002;415:96–99
  15. Lin SJ , Defossez PA , Guarente L . Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae . Science . 2000;289:2126–2128
  16. Howitz KT , Bitterman KJ , Cohen HY , et al.   Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan . Nature . 2003;425:191–196
  17. Meléndez A , Tallóczy Z , Seaman M , et al.   Autophagy genes are essential for dauer development and life-span extension in C. elegans . Science . 2003;301:1387–1391
  18. Bluher M , Kahn BB , Kahn CR . Extended longevity in mice lacking the insulin receptor in adipose tissue . Science . 2003;299:572–574
  19. Murphy CT , McCarroll SA , Bargmann CI , et al.   Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans . Nature . 2003;424:277–284
  20. Dillin A , Crawford DK , Kenyon C . Timing requirements for insulin/IGF-1 signaling in C. elegans . Science . 2002;298:830–834
  21. Middleton E , Kandaswami C , Theoharides TC . The effects of plant flavonoids on mammalian cells (implications for inflammation, heart disease, and cancer) . Pharmacol Rev . 2000;52:673–751
  22. Tapiero H , Tew KD , Ba GN , et al.   Polyphenols (do they play a role in the prevention of human pathologies?) . Biomed Pharmacother . 2002;56:200–207
  23. Weiss JB , Suyama KL , Lee HH , et al.   Jelly belly (a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation) . Cell . 2001;107:387–398
  24. Dudai Y . Neurobiology (Fear thou not) . Nature . 2003;421:325–327
  25. Shumyatsky GP , Tsvetkov E , Malleret G , et al.   Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear . Cell . 2002;111:905–918
  26. Turton MD , O’Shea D , Gunn I , et al.   A role for glucagon-like peptide-1 in the central regulation of feeding . Nature . 1996;379:69–72
  27. Yamada S , Komatsu M , Sato Y , et al.   Time-dependent stimulation of insulin exocytosis by 3′,5′-cyclic adenosine monophosphate in the rat islet β cell . Endocrinology . 2002;143:4203–4209
  28. During MJ , Cao L , Zuzga DS , et al.   Glucagon-like peptide-1 receptor is involved in learning and neuroprotection . Nat Med . 2003;9:1173–1179
  29. Wu JT , Kral JG . Ghrelin (integrative neuroendocrine peptide in health and disease) . Ann Surg . 2004;239:464–474
  30. Cummings DE , Overduin J , Foster-Schubert KE . Gastric bypass for obesity (mechanisms of weight loss and diabetes resolution) . J Clin Endo Metab . 2004;89:2608–2615
  31. Valdez GR , Zorrilla EP , Rivier J , et al.   Locomotor suppressive and anxiolytic-like effects of urocortin 3 a highly selective type 2 corticotropin-releasing factor agonist . Brain Res . 2003;980:206–212
  32. Herranz R . Cholecystokinin antagonists (pharmacological and therapeutic potential) . Med Res Rev . 2003;23:559–605
  33. Dudley CA , Erbel-Sieler C , Estill SJ , et al.   Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice . Science . 2003;301:379–383
  34. Qu D , Ludwig O , Gammeltoft S , et al.   A role for melanin-concentrating hormone in the central regulation of feeding behaviour . Nature . 1996;380:243–247
  35. Xu B , Goulding EH , Zang K , et al.   Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor . Nat Neurosci . 2003;7:736–742
  36. Volkow ND , Wang GJ , Maynard L , et al.   Brain dopamine is associated with eating behaviors in humans . Int J Eat Disord . 2003;33:136–142
  37. Phillips PEM , Stuber GD , Heien MLAV , et al.   Subsecond dopamine release promotes cocaine seeking . Nature . 2003;422:614–618
  38. Timofeeva E , Richard D . Activation of the central nervous system in obese Zucker rats during food deprivation . J Comp Neurol . 2001;441:71–89
  39. Björntorp P . Do stress reactions cause abdominal obesity and comorbidities? . Obes Rev . 2001;2:73–86
  40. McEwen BS . Allostasis and allostatic load (implications for neuropsychopharmacology) . Neuropsychopharmacology . 2000;22:108–124
  41. Tsigos C , Chrousos GP . Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress . J Psychosom Res . 2002;53:865–871
  42. Gohil BC , Rosenblum LA , Coplan JD , et al.   Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity . CNS Spect . 2001;6:581–589
  43. Bronstein D , Schafer M , Watson S , et al.   Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius (detection of POMC mRNA) . Brain Res . 1992;587:269–275
  44. Huszar D . Target disruption of the melanocortin-4 receptor results in obesity in mice . Cell . 1977;88:131–141
  45. Cone R . The melanocortin receptors (agonists, antagonists, and the hormonal control of pigmentation) . Recent Progr Horm Res . 1996;51:287–318
  46. Branson R , Potoczna N , Kral JG , et al.   Binge eating is a major phenotypic characteristic of melanocortin-4 receptor gene mutations . N Eng J Med . 2003;348:1096–1103
  47. Farooqi IS , Keogh JM , Yeo GSH , et al.   Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene . N Eng J Med . 2003;348:1085–1095
  48. Epel E , Lapidus R , McEwen B , et al.   Stress may add bite to appetite in women (a laboratory study of stress-induced cortisol and eating behavior) . Psychoneuroendocrinology . 2001;26:37–49
  49. Roemmich JN , Wright SM , Epstein LH . Dietary restraint and stress-induced snacking in youth . Obes Res . 2002;10:1120–1128
  50. Pecoraro N , Reyes F , Gomes F , et al.   Chronic stress promotes palatable feeding, which reduces signs of stress (feed-forward and feedback effects of chronic stress) . Endocrinology . 2004;145:3754–3762
  51. Dallman MF , Pecoraro N , Akana SF , et al.   Chronic stress and obesity (a new view of “comfort food.”) . Proc Natl Acad Sci USA . 2003;100:11696–11701
  52. Coplan J , Andrews MW , Rosenblum LA , et al.   Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors (implications for the pathophysiology of mood and anxiety disorders) . Proc Natl Acad Sci . 1996;93:1619–1623
  53. Gohil BC , Smith ELP , Banerji MA , et al.   Neurochemical precursors of adult obesity in monkeys . Am J Clin Nutr . 2002;75(2 Suppl):346S–347S
  54. Kaufman D , Shorman I , Smith ELP , et al.   Early-life stress causes insulin resistance in juvenile bonnet macaques . Obes Res . 2005;13: in press
  55. Kaufman D , Coplan J , Mathew S , et al.   Brain asymmetry and the development of obesity in bonnet macaques [abstract] . Obes Res . 2003;11(Suppl):A71
  56. Mathew SJ , Shungu DC , Mao X , et al.   A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors . Biol Psychiatry . 2003;54:727–735
  57. Kral JG , Lentes KU , Horber FF . Binge eating as a phenotype of melanocortin-4 receptor gene mutations . N Eng J Med . 2003;349:608–609
  58. Potoczna N , Branson R , Piec G , et al.   Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity . J Gastrointest Surg . 2004;8:971–982
  59. Schwartz MW . Brain pathways controlling food intake and body weight . Exp Biol Med . 2001;226:978–981
  60. Kral JG , Kissileff HR , Schaffner F . Eating behavior as a determinant of fatty liver and abdominal obesity (“le foie gras chez l’homme”) . Int J Obes . 1991;15(Suppl 1):84
  61. Kral JG , Buckley MC , Kissileff  , et al.   Metabolic correlates of eating behavior in severe obesity . Int J Obes . 2001;25:258–264
  62. Kral JG . Morbidity of severe obesity . Surg Clin N Am . 2001;81:1039–1061
  63. Richards MP , Schulting RJ , Hedges RE . Archaeology (sharp shift in diet at onset of Neolithic) . Nature . 2003;425:366
  64. Borlaug NE . The impact of agricultural research on Mexican wheat production . Trans NY Acad Sci . 1958;20:278–295
  65. World Health Organization . Obesity (preventing and managing the global epidemic) . Report of a WHO consultation on obesity, Geneva . 1998;
  66. Mi J , Law C , Zhang KL , et al.   Effects of infant birth weight and maternal body mass index in pregnancy on components of the insulin resistance syndrome in China . Ann Intern Med . 2000;132:253–260
  67. Vague J . La différenciation sexuelle (facteur determinant des formes de l’obesité) . Presse Med . 1947;30:339–340
  68. Kreier F , Fliers E , Voshol PJ , et al.   Selective parasympathetic innervation of subcutaneous and intra-abdominal fat (functional implications) . J Clin Invest . 2002;110:1243–1250
  69. Williams DL , Bowers RR , Bartness TJ , et al.   Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat . Endocrinology . 2003;144:4692–4697
  70. Qi Y , Takahashi N , Hileman SM , et al.   Adiponectin acts in the brain to decrease body weight . Nat Med . 2004;10:524–529
  71. Obici S , Zhang BB , Karkanias G , et al.   Hypothalamic insulin signaling is required for inhibition of glucose production . Nat Med . 2002;8:1376–1382
  72. Reaven GM . Role of insulin resistance in human disease . Diabetes . 1988;37:1595–1607
  73. Hansen BC . The metabolic syndrome X . Ann NY Acad Sci . 1999;892:1–24
  74. Wilson FH , Hariri A , Fahri A , et al.   A cluster of metabolic defects caused by mutation in a mitochondrial tRNA . Science . 2004;306:1190–1194
  75. Shen W , Wang Z , Punyanita M , et al.   Adipose tissue quantification by imaging methods (a proposed classification system) . Obes Res . 2003;13:15–16
  76. Hill JO , Wyatt HR , Reed GW , et al.   Obesity and the environment (where do we go from here?) . Science . 2003;299:853–858
  77. Koplan JP , Dietz WH . Caloric imbalance and public health policy . JAMA . 1999;282:1579–1582
  78. Whitaker RC . Obesity prevention in pediatric primary care (four behaviors to target) . Arch Pediatr Adolesc Med . 2003;157:725–727
  79. Kral JG . Preventing and treating obesity in girls and young women to curb the epidemic . Obes Res . 2004;12:1539–1546
  80. Agras WS , Kraemer HC , Berkowitz RI , et al.   Influence of early feeding style on adiposity at 6 years of age . J Pediatr . 1990;116:805–809
  81. Sturm R . Increases in clinically severe obesity in the United States, 1986–2000 . Arch Intern Med . 2003;163:2146–2148
  82. Williamson DF , Thompson TJ , Anda RF , et al.   Body weight and obesity in adults and self-reported abuse in childhood . Int J Obes . 2002;26:1075–1082
  83. King TK , Clarke MM , Pera V . History of sexual abuse and obesity treatment outcome . Addict Behav . 1996;21:283–290
  84. Dingemans AE , Bruna MJ , van Furth EF . Binge eating (a review) . Int J Obes . 2002;26:299–307
  85. Kalarchian MA , Marcus MD , Wilson GT , et al.   Binge eating among gastric bypass patients at long-term follow-up . Obes Surg . 2002;12:270–275
  86. Kral JG . Behavioral effects of vagotomy in humans . J Auton Nerv Syst . 1983;9:273–281
  87. Lustig RH . Autonomic dysfunction of the beta-cell and the pathogenesis of obesity . Rev Endocr Metab Disord . 2003;4:23–32
  88. Guss JL , Kissileff HR , Devlin MJ , et al.   Binge size increases with body mass index in women with binge-eating disorder . Obes Res . 2002;10:1021–1029
  89. Mair W , Goymer P , Pletcher SD , et al.   Demography of dietary restriction and death of Drosophila . Science . 2003;301:1731–1733

PII: S1550-7289(04)00011-5

doi: 10.1016/j.soard.2004.12.009

Surgery for Obesity and Related Diseases
Volume 1, Issue 1 , Pages 25-34 , January 2005

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