Surgery for Obesity and Related Diseases
Volume 6, Issue 1 , Pages 54-58 , January 2010

Incidence of postoperative gallstone disease after antiobesity surgery: population-based study from Sweden

  • Eduard Jonas, M.D., Ph.D.

      Affiliations

    • Division of surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Richard Marsk, M.D.

      Affiliations

    • Division of surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Finn Rasmussen, M.D., Ph.D.

      Affiliations

    • Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Jacob Freedman, M.D., Ph.D.

      Affiliations

    • Division of surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationReprint requests: Jacob Freedman, M.D., Ph.D., Department of Surgery, Danderyd Hospital, Stockholm SE-182 88 Sweden

Received 31 January 2009 ,Accepted 19 March 2009.

References 

  1. Sjöström L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351:2683–2693
  2. Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741–752
  3. Amaral JF, Thompson WR. Gallbladder disease in the morbidly obese. Am J Surg. 1985;149:551–557
  4. Shiffman ML, Sugerman HJ, Kellum JM, Brewer WH, Moore EW. Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol. 1991;86:1000–1005
  5. Taylor J, Leitman IM, Horowitz M. Is routine cholecystectomy necessary at the time of Roux-en-Y gastric bypass?. Obes Surg. 2006;16:759–761
  6. Weinsier RL, Ullmann DO. Gallstone formation and weight loss. Obes Res. 1993;1:51–56
  7. Patel KR, White SC, Tejirian T, et al. Gallbladder management during laparoscopic Roux-en-Y gastric bypass surgery: routine preoperative screening for gallstones and postoperative prophylactic medical treatment are not necessary. Am Surg. 2006;72:857–861
  8. Wudel LJ, Wright JK, Debelak JP, Allos TM, Shyr Y, Chapman WC. Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study. J Surg Res. 2002;102:50–56
  9. Tucker ON, Fajnwaks P, Szomstein S, Rosenthal RJ. Is concomitant cholecystectomy necessary in obese patients undergoing laparoscopic gastric bypass surgery?. Surg Endosc. 2008;22:2450–2454
  10. Caruana JA, McCabe MN, Smith AD, Camara DS, Mercer MA, Gillespie JA. Incidence of symptomatic gallstones after gastric bypass: is prophylactic treatment really necessary?. Surg Obes Relat Dis. 2005;1:564–568
  11. Sugerman HJ, Brewer WH, Shiffman ML, et al. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg. 1995;169:91–97
  12. Villegas L, Schneider B, Provost D, et al. Is routine cholecystectomy required during laparoscopic gastric bypass?. Obes Surg. 2004;14:206–211
  13. Dhabuwala A, Cannan RJ, Stubbs RS. Improvement in co-morbidities following weight loss from gastric bypass surgery. Obes Surg. 2000;10:428–435
  14. Portenier DD, Grant JP, Blackwood HS, Pryor A, McMahon RL, DeMaria E. Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3:476–479
  15. Shiffman ML, Shamburek RD, Schwartz CC, Sugerman HJ, Kellum JM, Moore EW. Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology. 1993;105:1200–1208
  16. Shiffman ML, Sugerman HJ, Kellum JH, Brewer WH, Moore EW. Gallstones in patients with morbid obesity: relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord. 1993;17:153–158
  17. Erlinger S. Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol. 2000;12:1347–1352
  18. Shaffer EA. Gallstone disease: epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006;20:981–996
  19. O'Brien PE, Dixon JB. A rational approach to cholelithiasis in bariatric surgery: its application to the laparoscopically placed adjustable gastric band. Arch Surg. 2003;138:908–912
  20. Li VK, Pulido N, Fajnwaks P, Szomstein S, Rosenthal R. Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy. Surg Endosc. 2009 April 3;
  21. Cirillo DJ, Wallace RB, Rodabough RJ, et al. Effect of estrogen therapy on gallbladder disease. JAMA. 2005;293:330–339
  22. Persson G, Enochsson L, Sandblom G. 2007 report from the Swedish national registry for cholecystectomies. www.ucr.uu.se/gallriks/index.php?option=com_docman&task=doc_download&gid=56&&Itemid=44Accessed January 30, 2009

 Supported by the Swedish Research Council and the Stockholm County Council.

PII: S1550-7289(09)00367-0

doi: 10.1016/j.soard.2009.03.221

Surgery for Obesity and Related Diseases
Volume 6, Issue 1 , Pages 54-58 , January 2010

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