Surgery for Obesity and Related Diseases
Volume 6, Issue 6 , Pages 676-680 , November 2010

Roux-en-Y gastric bypass alters tumor necrosis factor-α but not adiponectin signaling in immediate postoperative period in obese rats

Presented at the Plenary Session of the 2009 American Society for Metabolic and Bariatric Surgery Annual Meeting, Grapevine, Texas

  • Drew A. Rideout, M.D.

      Affiliations

    • Department of Surgery, James A. Haley Veterans Affairs Medical Center, University of South Florida, Tampa, Florida
    • ,
  • Yanhua Peng, Ph.D.

      Affiliations

    • Department of Surgery, James A. Haley Veterans Affairs Medical Center, University of South Florida, Tampa, Florida
    • ,
  • Steven S. Rakita, M.D.

      Affiliations

    • Department of Surgery, James A. Haley Veterans Affairs Medical Center, University of South Florida, Tampa, Florida
    • ,
  • Karan Desai, B.S.

      Affiliations

    • Department of Surgery, James A. Haley Veterans Affairs Medical Center, University of South Florida, Tampa, Florida
    • ,
  • William R. Gower Jr, Ph.D.

      Affiliations

    • Department of Research, University of South Florida, Tampa, Florida
    • ,
  • Min You, Ph.D.

      Affiliations

    • Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida
    • ,
  • Michel M. Murr, M.D., F.A.C.S.

      Affiliations

    • Department of Surgery, James A. Haley Veterans Affairs Medical Center, University of South Florida, Tampa, Florida
    • Corresponding Author InformationCorrespondence: Michel M. Murr, M.D., F.A.C.S., University of South Florida c/o Tampa General Hospital, P.O. Box 1289, Tampa, FL 33601

Received 10 November 2009 ,Revised 20 April 2010 ,Accepted 23 May 2010.

References 

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  8. Rideout DA, Peng Y, Rakita SS, Gower WR, You M, Murr MM. Roux-en-Y gastric bypass downregulates hepatic stearoyl-CoA desaturase 1 independently of serum leptin in obese rats. J Surg Res. 2009;151:244
  9. Rideout DA, Rakita SS, Peng Y, Gower WR, Murr MM. Practical considerations and survival techniques for a rat model of Roux-en-Y gastric bypass. Gastroenterology. 2008;134:A877
  10. Cai D. Local and systemic insulin resistance resulting from hepatic activation of IKKb and NF-KB. Nature Med. 2005;11:183–190
  11. Kral JG, Thung SN, Biron S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery. 2004;135:48–58
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  13. Nagata K, Suzuki H, Sakaguchi S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or acoholic steatohepatitis. J Toxicol Sci. 2007;32:453–468
  14. Peng Y, Gallagher S, Landmann R, Murr M. The role of p65NF-kappaB/RelA in pancreatitis-induced Kupffer cells apoptosis. J Gastrointest Surg. 2006;10:837–847
  15. Peng Y, Sigua C, Rideout D, Murr M. Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis. Surgery. 2008;143:679–685
  16. Peng Y, Sigua C, Karsonovich C, Murr M. Protein kinase C-zeta regulates Kupffer cell apoptosis during experimental sepsis. J Gastrointest Surg. 2007;11:1712–1721
  17. Kadowaki T, Yamauchi T, Kubota N, Hara H, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes and metabolic syndrome. J Clin Invest. 2006;116:1784–1792
  18. Dubois SD, Heilbronn LK, Smith SH, Albu JB, Kelley DE, Ravussin E. Decreased expression of adipogenic genes in obese subjects with type 2 diabetes. Obesity. 2006;14:1543–1552
  19. Yamaguchi N, Argueta JG, Masuhiro Y, et al. Adiponectin inhibits toll-like receptor family-induced signaling. FEBS Lett. 2005;579:6821–6826
  20. Xu A, Wang Y, Keshaw H, et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112:91–100
  21. Swarbrick MM, Austrheim-Smith IT, Stanhope KL, et al. Circulating concentrations of high-molecular weight adiponectin are increased following Roux-en-Y gastric bypass surgery. Diabetologia. 2006;49:2552–2558
  22. Peng Y, Rideout DA, Rakita SS, et al. Roux-en-Y gastric bypass reduces oxidative stress and downregulates pro-inflammatory genes in livers of obese rats and in Kupffer cells via an AMPK-dependent pathway. J Surg Res. 2009;151:244–245

 Supported by 2008 American Society for Metabolic and Bariatric Surgery Research Grant Award 28.

PII: S1550-7289(10)00525-3

doi: 10.1016/j.soard.2010.05.017

Surgery for Obesity and Related Diseases
Volume 6, Issue 6 , Pages 676-680 , November 2010

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