Abstract
Background
Gut microbiota may induce obesity, diabetes, and metabolic syndrome. Different weight
reduction programs may induce different changes in gut microbiota.
Objectives
To assess the changes in gut microbiota between obese adults who participated in 2
different weight reduction programs, the dietary counseling (DC) group and sleeve
gastrectomy (SG) group, for 3 months.
Setting
A University Hospital.
Methods
Ten obese participants from each group were matched according to sex, age, and body
mass index. Gut microbiota compositions were determined by metagenomics using next-generation
sequencing before and after treatment. Anthropometric indices, metabolic factors,
and gut microbiota were compared between and within groups.
Results
After 3 months of treatment, compared with subjects in DC group, subjects in SG group
experienced a greater reduction in body weight, body mass index, body fat, waist and
hip circumference, diastolic blood pressure, hemoglobin, insulin, insulin resistance,
glutamate pyruvate transaminase, blood urine nitrogen, and glycated hemoglobin (HbA1C).
A total of 8, 17, and 46 species experienced significant abundance changes in DC,
in SG, and between the 2 groups, respectively. Diversity of the gut flora increased
in SG and between the 2 groups after treatment. The weight change over the course
of the weight loss program was further adjusted and only 4 species, including Peptoniphilus lacrimalis 315 B, Selenomonas 4 sp., Prevotella 2 sp., and Pseudobutyrivibrio sp., were found to be significantly different between the 2 weight loss programs. These
4 species may be the different gut microbiota change between internal and surgical
weight reduction programs.
Conclusions
There are significant differences not only in anthropometric indices and metabolic
factors but also in gut microbiota change between the 2 programs.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Surgery for Obesity and Related DiseasesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
Obesity and overweight [homepage on the Internet]. Geneva: World Health Organization; c2019 [updated 2018 Feb 16; cited 2018 Dec 25. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
- Prevalence of obesity among adults and youth: United States, 2011-2014.NCHS Data Brief. 2015; : 1-8
- Cardiovascular and all-cause mortality in relation to various anthropometric measures of obesity in Europeans.Nutr Metab Cardiovasc Dis. 2015; 25: 295-304
- Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.Mol Genet Genomics. 2015; 290: 1191-1221
- Gut microbiota and the pathogenesis of insulin resistance.Curr Diab Rep. 2011; 11: 154-159
- Gut microbiota and obesity.Cell Mol Life Sci. 2016; 73: 147-162
- Gut microbiota, obesity and diabetes.Postgrad Med J. 2016; 92: 286-300
- Linking gut microbiota and inflammation to obesity and insulin resistance.Physiology (Bethesda). 2016; 31: 283-293
- The new era of treatment for obesity and metabolic disorders: evidence and expectations for gut microbiome transplantation.Front Cell Infect Microbiol. 2016; 6: 15
- Introduction to the human gut microbiota.Biochem J. 2017; 474: 1823-1836
- Host-bacterial mutualism in the human intestine.Science. 2005; 307: 1915-1920
- The gut microbiome and obesity.Curr Oncol Rep. 2016; 18: 45
- The human gut microbiome: a review of the effect of obesity and surgically induced weight loss.JAMA Surg. 2013; 148: 563-569
- Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.Gut. 2016; 65: 426-436
- The gut microbiota as an environmental factor that regulates fat storage.Proc Natl Acad Sci U S A. 2004; 101: 15718-15723
- Gut microbiota from twins discordant for obesity modulate metabolism in mice.Science. 2013; 3411241214
- Microbiota depletion promotes browning of white adipose tissue and reduces obesity.Nat Med. 2015; 21: 1497-1501
- Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models.Gut. 2010; 59: 1635-1642
- Microbial ecology: human gut microbes associated with obesity.Nature. 2006; 444: 1022-1023
- An obesity-associated gut microbiome with increased capacity for energy harvest.Nature. 2006; 444: 1027-1031
- Alterations of gut microbiota after Roux-en-Y gastric bypass and sleeve gastrectomy in Sprague-Dawley rats.Obes Surg. 2017; 27: 295-302
- Gut microbiota composition correlates with changes in body fat content due to weight loss.Benef Microbes. 2015; 6: 431-439
- Richness of human gut microbiome correlates with metabolic markers.Nature. 2013; 500: 541-546
- Losing weight for a better health: role for the gut microbiota.Clin Nutr Exp. 2016; 6: 39-58
- Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption.Biomed Res Int. 2015; 2015806248
- Human gut microbiota in obesity and after gastric bypass.Proc Natl Acad Sci U S A. 2009; 106: 2365-2370
- Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers.Diabetes. 2010; 59: 3049-3057
- Differential changes in gut microbiota after gastric bypass and sleeve gastrectomy bariatric surgery vary according to diabetes remission.Obes Surg. 2017; 27: 917-925
- Interplay between weight loss and gut microbiota composition in overweight adolescents.Obesity (Silver Spring). 2009; 17: 1906-1915
- Estimating the number of classes via sample coverage.J Am Stat Assoc. 1992; 87: 210-217
- Stopping rules and estimation for recapture debugging with unequal failure rates.Biometrika. 1993; 80: 193-201
- Bariatric surgery versus intensive medical therapy in obese patients with diabetes.N Engl J Med. 2012; 366: 1567-1576
- Gut microbiota and body weight in school-aged children: the KOALA Birth Cohort Study.Obesity. 2018; 26: 1767-1776
- Characterization of the gut microbial community of obese patients following a weight-loss intervention using whole metagenome shotgun sequencing.PLoS One. 2016; 11e0149564
- The gut microbiota in conventional and serrated precursors of colorectal cancer.Microbiome. 2016; 4: 69
- Impacts of gut bacteria on human health and diseases.Int J Mol Sci. 2015; 16: 7493-7519
- Adiposity and cancer at major anatomical sites: umbrella review of the literature.BMJ. 2017; 356: j477
- Global burden of cancer attributable to high body-mass index in 2012: a population-based study.Lancet Oncol. 2015; 16: 36-46
- Effects of bariatric surgery on mortality in Swedish obese subjects.N Engl J Med. 2007; 357: 741-752
- Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery.J Intern Med. 2013; 273: 219-234
- Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach.Hepatology. 2017; 65: 451-464
Article info
Publication history
Published online: January 31, 2019
Accepted:
January 28,
2019
Received in revised form:
December 20,
2018
Received:
September 9,
2018
Footnotes
This study was financially supported by grants from Ministry of Science and Technology, Taiwan (MOST 106-2314-B-039-031 and 107-2314-B-039 -055 -MY3), China Medical University Hospital, Taiwan (CMUH105-REC1-091 and DMR-107-086), and from the Ministry of Health and Welfare, Taiwan (MOHW 107-TDU-B-212-123004).
Identification
Copyright
© 2019 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
