Highlights
- •Myopenia and adiposity show prognostic effects on DFS in patients with colorectal cancer
- •subcutaneous adipose tissue reflects an energetic storage favorable to face colorectal cancer
- •Muscle mass loss may represent a modifiable risk factor in colorectal cancer
- •Interpretation of CRP level must take into account adiposity to avoid unnecessary interventions
Abstract
Background
Anthropometric data as prognostic factors of colorectal cancer are promising but contradictory.
The aim of this study was to assess the preoperative body composition profiles as
predictive factors for postoperative, oncologic, and inflammation outcomes.
Objectives
We sought to assess the impact of body composition profiles on short- and long-term
outcomes and on postoperative inflammatory response in a clinical setting for patients
following curative intent surgery for colorectal cancer.
Setting
University hopsital
Methods
We analyzed 122 patients from a prospective cohort (IMACORS) with colorectal cancer
undergoing curative-intent surgery from 2011 to 2014. Musculature, total, visceral,
and subcutaneous adiposity were measured from a preoperative CT scan and outcomes
were compared between profiles.
Results
Preoperative myopenia was an independent predictive factor of recurrence (HR = 3.3
95% CI = 1.6–6.9; P = .002) while subcutaneous adiposity was a protective factor (HR = .4 95% CI = .2–.9;
P = .03). No anthropometric measurement was predictive of overall survival and postoperative
intra abdominal infection was not determined by body composition profiles. Preoperative
and D4 CRP levels were significantly higher in patients with subcutaneous adiposity.
Conclusions
Myopenia and subcutaneous adiposity seemed to have independent and opposite prognostic
effects on recurrence. Muscle mass loss may represent a modifiable risk factor while
the amount of subcutaneous adipose tissue reflects an energetic storage favorable
to face this pathologic process.
Keywords
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Article info
Publication history
Published online: October 26, 2020
Accepted:
October 17,
2020
Received:
May 5,
2020
Identification
Copyright
© 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
