Abstract
Background
Bariatric surgery is an increasingly popular treatment for patients with severe obesity
and related health issues (e.g., diabetes, cardiovascular disease). Studies have identified
alterations in functional connectivity both in obesity and following surgical treatment
for severe obesity.
Objective
This study aimed to assess brain function via resting-state within-network connectivity
in bariatric surgery patients with severe obesity.
Setting
University hospital.
Methods
Thirty-four bariatric surgery patients completed functional neuroimaging at baseline
and postoperatively (goal, 12 weeks; actual, 16 weeks, on average). They also self-reported
health information. Baseline resting-state functional connectivity (RSFC) was predicted
by baseline age, body mass index (BMI), continuous positive airway pressure use, and
reported history of rheumatoid arthritis and type 2 diabetes. Change in RSFC was assessed
using the same predictors. This model was run with and without controlling for baseline
RSFC.
Results
Higher baseline BMI predicted lower baseline RSFC in 3 networks. Lower baseline RSFC
also was related to rheumatoid arthritis and type 2 diabetes. Difference between baseline
and follow-up RSFC was strongly negatively associated with baseline RSFC. Controlling
for baseline RSFC, type 2 diabetes negatively predicted RSFC difference.
Conclusions
RSFC may reflect brain dysfunction in patients with obesity and related diseases.
That less connectivity at baseline predicted greater positive change suggests that
RSFC may be a biomarker of neurocognitive improvement following bariatric surgery.
Diseases more prevalent in patients with obesity (e.g., rheumatoid arthritis and type
2 diabetes) along with elevated BMI negatively affect RSFC likely through inflammatory
pathways.
Keywords
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Article info
Publication history
Published online: December 17, 2022
Accepted:
December 10,
2022
Received:
June 2,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Inc. on behalf of American Society for Metabolic and Bariatric Surgery.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Paired Editorial: Resting State Network Functional Connectivity Pre- and Post-Bariatric SurgerySurgery for Obesity and Related Diseases
