Comment on: The male patient with obesity undergoing bariatric-metabolic surgery: Changes in testosterone levels correlate with weight loss after OAGB and RYGB

Ann-Cathrin Koschker; Florian Seyfried

doi:10.1016/j.soard.2023.01.009

Comment on: The male patient with obesity undergoing bariatric-metabolic surgery: Changes in testosterone levels correlate with weight loss after OAGB and RYGB

Ann-Cathrin Koschker
Ann-Cathrin Koschker
Affiliations
Dept. of Internal Medicine I, Division of Endocrinology and Diabetology, University Hospital Würzburg, Würzburg, Germany
Dept. Clinical Research & Epidemiology, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany
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Florian Seyfried
Florian Seyfried
Correspondence
Corresponding author Prof. Florian Seyfried, MD Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery University Hospital Würzburg Oberdürrbacherstr. 6, 97080 Würzburg, Germany Tel. +49-931-201-31046 Fax +49 931 201-39994
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Affiliations
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany
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Published:January 18, 2023DOI:https://doi.org/10.1016/j.soard.2023.01.009

Male obesity-associated secondary hypogonadism (MOSH) is among a number of comorbidities and health consequences associated with obesity ⁽

¹

Carrageta DF, Oliveira PF, Alves MG, et al. Obesity and male hypogonadism: Tales of a vicious cycle..Obes Rev. 2019 Aug;20(8):1148-1158.

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⁾. Although frequently neglected, this disorder has a relevant impact on both patients’ quality of life but also potentially life expectancy. Obesity has been identified as a primary cause of secondary hypogonadism and reproductive dysfunction. Adipose tissue aromatase can reduce testosterone levels by irreversibly converting testosterone to estradiol. Low testosterone levels may lead to alterations in body composition and promote abdominal fat accumulation while obesity, in turn, can further reduce testosterone levels. Additionally, high estradiol concentrations have shown to mediate deleterious effects on male gonadal function. Thus, this bidirectional relationship of obesity-hypogonadism can easily become a vicious cycle.

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Literature:

Carrageta DF, Oliveira PF, Alves MG, et al. Obesity and male hypogonadism: Tales of a vicious cycle..Obes Rev. 2019 Aug;20(8):1148-1158.
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Jedamzik J, Bichler C, Felsenreich DM, et al. The male patient with obesity undergoing bariatric-metabolic surgery: Changes in testosterone levels correlate with weight loss after OAGB and RYGB, SOARD 2022, Epub ahead of print.
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Accepted: January 15, 2023

Received: January 6, 2023

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DOI: https://doi.org/10.1016/j.soard.2023.01.009

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The male patient with obesity undergoing metabolic and bariatric surgery: changes in testosterone levels correlate with weight loss after one-anastomosis gastric bypass and Roux-en-Y gastric bypass
Surgery for Obesity and Related Diseases
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  Male obesity secondary hypogonadism (MOSH) is a common disease among men with obesity and can be associated with metabolic syndrome and a variety of metabolic problems ultimately leading to androgen deficiency. Metabolic and bariatric surgery is a well-established treatment option associated with significant weight loss and reduction in metabolic co-morbidities.
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Comment on: The male patient with obesity undergoing bariatric-metabolic surgery: Changes in testosterone levels correlate with weight loss after OAGB and RYGB

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