Highlights
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1.Bariatric surgery induces changes in the short-chain fatty acids (SCFA) profile.
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2.Straight SCFA are reduced after bariatric surgery, while branched SCFA increased.
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3.Changes in SCFA levels are associated with weight loss.
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4.Increased levels of branched SCFA are associated with improved insulin sensitivity.
Abstract
Background
Obesity has reached epidemic dimensions in recent decades. Bariatric surgery (BS)
is one of the most effective interventions for weight loss and metabolic improvement
in patients with obesity. Short-chain fatty acids (SCFA) are gut microbiota-derived
metabolites with a key role in body weight control and insulin sensitivity. Although
BS is known to induce significant changes in the gut microbiota composition, its impact
on the circulating levels of certain metabolites produced by the gut microbiota such
as SCFA remains poorly understood.
Objective
To determine the impact of BS on the circulating SCFA levels in patients with severe
obesity.
Setting
University hospital.
Methods
An observational, prospective study was performed on 51 patients undergoing Roux-en-Y
gastric bypass. Plasma samples were collected at baseline (1 day before surgery) and
at 6 and 12 months after BS. Plasma SCFA levels were determined by liquid chromatography–mass
spectrometry.
Results
The results revealed significant changes in the circulating levels of SCFA after BS.
A marked increase in propionate, butyrate, isobutyrate, and isovalerate levels and
a decrease in acetate, valerate, hexanoate, and heptanoate levels were observed 12
months after BS. Furthermore, the changes in the levels of propionate, butyrate, and
isobutyrate negatively correlated with changes in body mass index, while those of
isobutyrate correlated negatively with changes in the homeostatic model assessment
for insulin resistance index.
Conclusion
These results suggest that propionate, butyrate, and isobutyrate levels could be related
to weight loss and improved insulin sensitivity in patients with severe obesity after
BS.
Keywords
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Article info
Publication history
Published online: January 30, 2023
Accepted:
December 1,
2022
Received:
September 1,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
María A. Martínez-Sánchez and Andrés Balaguer-Román contributed equally to this work and share first authorship.
Identification
Copyright
© 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
