Highlights
- •Metabolic surgery is associated with lower risk of developing obesity-associated cancer.
- •Metabolic surgery is associated with lower risk of cancer-related mortality.
- •There is a dose-dependent response between weight loss and cancer risk: the greater the weight loss, the lower the risk of cancer.
- •Available data suggest substantial weight loss (over 20-25%) is necessary to significantly reduce cancer risk in people with obesity.
Abstract
Obesity incidence continues to rise globally along with obesity-associated conditions,
which heavily burden individuals’ quality of life and healthcare systems. Evidence
regarding the power of metabolic and bariatric surgery to treat obesity has, fortunately,
brought to light how substantial and sustained weight loss can mitigate adverse clinical
outcomes of obesity and metabolic disease. Obesity-associated cancer has been an important
focus of studies in recent decades to further elucidate what impact metabolic surgery
could have on incidence of cancer and cancer-related mortality. The SPLENDID (Surgical
Procedures and Long-term Effectiveness in Neoplastic Disease Incidence and Death)
study is one of the recent large cohort studies that highlights the power of substantial
weight loss and the long-term benefits to patients with obesity in preventing cancer.
This review of SPLENDID aims to highlight both consistency of results with prior studies
and new findings unexplored previously.
Keywords
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Article info
Publication history
Published online: February 06, 2023
Accepted:
January 29,
2023
Received:
January 24,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
