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Original article|Articles in Press

What is currently known about the association between bariatric surgery and cancer

  • Daniel P. Schauer
    Correspondence
    Correspondence: Daniel P. Schauer, M.D., M.Sc., Department of Internal Medicine, University of Cincinnati College of Medicine, P.O. Box 670535, Cincinnati, OH 45267-0535.
    Affiliations
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio
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Published:February 06, 2023DOI:https://doi.org/10.1016/j.soard.2023.01.028
What is currently known about the association between bariatric surgery and cancer
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      Abstract

      Background

      Obesity increases the risk of multiple cancers.

      Objective

      The purpose of this manuscript is to review the high-quality studies that have provided the most compelling evidence around the association between bariatric surgery and cancer risk.

      Setting

      Literature review.

      Methods

      The literature was reviewed for large high quality observational studies with well matched controls. Identified studies were summarized in this review.

      Results

      Four large cohort studies were identified and summarized including the Swedish Obese Subjects study, the Utah cohorts, the Kaiser Permanente studies and the SPLENDID study. All four cohorts demonstrated a strong association between bariatric surgery and a reduction in cancer risk. Two of the cohorts showed a reduction in cancer related mortality, and two of the cohorts found a dose-response between amount of weight loss following bariatric surgery and cancer risk.

      Conclusions

      The evidence that bariatric surgery is associated with a reduced risk of cancer is compelling.

      Keywords

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      Article info

      Publication history

      Published online: February 06, 2023
      Accepted: January 29, 2023
      Received: December 31, 2022

      Publication stage

      In Press Journal Pre-Proof

      Identification

      DOI: https://doi.org/10.1016/j.soard.2023.01.028

      Copyright

      © 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

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