Advertisement
Surgery for Obesity and Related Diseases
ASMBS
Advanced searchSave search
Original article|Articles in Press

What is currently known about the association between bariatric surgery and cancer

  • Daniel P. Schauer
    Correspondence
    Correspondence: Daniel P. Schauer, M.D., M.Sc., Department of Internal Medicine, University of Cincinnati College of Medicine, P.O. Box 670535, Cincinnati, OH 45267-0535.
    Affiliations
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Search for articles by this author
Published:February 06, 2023DOI:https://doi.org/10.1016/j.soard.2023.01.028
What is currently known about the association between bariatric surgery and cancer
Previous ArticleComment on: The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Bariatric Surgical Risk/Benefit Calculator: 1-year weight
Next ArticleObesity-associated cancer risk reduction after metabolic surgery: insights from the SPLENDID study and the path forward

      Abstract

      Background

      Obesity increases the risk of multiple cancers.

      Objective

      The purpose of this manuscript is to review the high-quality studies that have provided the most compelling evidence around the association between bariatric surgery and cancer risk.

      Setting

      Literature review.

      Methods

      The literature was reviewed for large high quality observational studies with well matched controls. Identified studies were summarized in this review.

      Results

      Four large cohort studies were identified and summarized including the Swedish Obese Subjects study, the Utah cohorts, the Kaiser Permanente studies and the SPLENDID study. All four cohorts demonstrated a strong association between bariatric surgery and a reduction in cancer risk. Two of the cohorts showed a reduction in cancer related mortality, and two of the cohorts found a dose-response between amount of weight loss following bariatric surgery and cancer risk.

      Conclusions

      The evidence that bariatric surgery is associated with a reduced risk of cancer is compelling.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery for Obesity and Related Diseases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Lauby-Secretan B.
        • Scoccianti C.
        • Loomis D.
        • et al.
        Body fatness and cancer--viewpoint of the IARC Working Group.
        N Engl J Med. 2016; 375: 794-798
        View in Article
        • Steele C.B.
        • Thomas C.C.
        • Henley S.J.
        • et al.
        Vital signs: trends in incidence of cancers associated with overweight and obesity - United States, 2005-2014.
        MMWR Morb Mortal Wkly Rep. 2017; 66: 1052-1058
        View in Article
        • Arnold M.
        • Renehan A.G.
        • Colditz G.A.
        Excess weight as a risk factor common to many cancer sites: words of caution when interpreting meta-analytic evidence.
        Cancer Epidemiol Biomarkers Prev. 2017; 26: 663-665
        View in Article
        • Byers T.
        • Sedjo R.L.
        Does intentional weight loss reduce cancer risk?.
        Diabetes Obes Metab. 2011; 13: 1063-1072
        View in Article
        • Sjostrom L.
        • Gummesson A.
        • Sjostrom C.D.
        • et al.
        Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial.
        Lancet Oncol. 2009; 10: 653-662
        View in Article
        • Anveden A.
        • Taube M.
        • Peltonen M.
        • et al.
        Long-term incidence of female-specific cancer after bariatric surgery or usual care in the Swedish Obese Subjects Study.
        Gynecol Oncol. 2017; 145: 224-229
        View in Article
        • Taube M.
        • Peltonen M.
        • Sjoholm K.
        • et al.
        Long-term incidence of colorectal cancer after bariatric surgery or usual care in the Swedish Obese Subjects study.
        PLoS One. 2021; 16e0248550
        View in Article
        • Taube M.
        • Peltonen M.
        • Sjoholm K.
        • et al.
        Association of bariatric surgery with skin cancer incidence in adults with obesity: a nonrandomized controlled trial.
        JAMA Dermatol. 2020; 156: 38-43
        View in Article
        • Adams T.D.
        • Stroup A.M.
        • Gress R.E.
        • et al.
        Cancer incidence and mortality after gastric bypass surgery.
        Obesity (Silver Spring). 2009; 17: 796-802
        View in Article
        • Adams T.D.
        • Gress R.E.
        • Smith S.C.
        • et al.
        Long-term mortality after gastric bypass surgery.
        N Engl J Med. 2007; 357: 753-761
        View in Article
        • Schauer D.P.
        • Feigelson H.S.
        • Koebnick C.
        • et al.
        Bariatric surgery and the risk of cancer in a large multisite cohort.
        Ann Surg. 2019; 269: 95-101
        View in Article
        • Schauer D.P.
        • Feigelson H.S.
        • Koebnick C.
        • et al.
        Association between weight loss and the risk of cancer after bariatric surgery.
        Obesity (Silver Spring). 2017; 25: S52-S57
        View in Article
        • Feigelson H.S.
        • Caan B.
        • Weinmann S.
        • et al.
        Bariatric surgery is associated with reduced risk of breast cancer in both premenopausal and postmenopausal women.
        Ann Surg. 2020; 272: 1053-1059
        View in Article
        • Aminian A.
        • Wilson R.
        • Al-Kurd A.
        • et al.
        Association of bariatric surgery with cancer risk and mortality in adults with obesity.
        JAMA. 2022; 327: 2423-2433
        View in Article
        • Ostlund M.P.
        • Lu Y.
        • Lagergren J.
        Risk of obesity-related cancer after obesity surgery in a population-based cohort study.
        Ann Surg. 2010; 252: 972-976
        View in Article
        • Derogar M.
        • Hull M.A.
        • Kant P.
        • Ostlund M.
        • Lu Y.
        • Lagergren J.
        Increased risk of colorectal cancer after obesity surgery.
        Ann Surg. 2013; 258: 983-988
        View in Article
        • Aravani A.
        • Downing A.
        • Thomas J.D.
        • Lagergren J.
        • Morris E.J.A.
        • Hull M.A.
        Obesity surgery and risk of colorectal and other obesity-related cancers: an English population-based cohort study.
        Cancer Epidemiol. 2018; 53: 99-104
        View in Article

      Article info

      Publication history

      Published online: February 06, 2023
      Accepted: January 29, 2023
      Received: December 31, 2022

      Publication stage

      In Press Journal Pre-Proof

      Identification

      DOI: https://doi.org/10.1016/j.soard.2023.01.028

      Copyright

      © 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX